Casey consults with start-ups, governments, and companies all over the world on challenges ranging from creating new products and services, to transforming organizational processes and behaviors. Industry leaders like Microsoft, Samsung, Cisco, and Johnson & Johnson, among others, have sought out her expertise to tackle their design and innovation challenges.

Before starting her own practice, Casey held executive leadership positions at the most respected design companies in the world. At IDEO, she led the digital experience group, focusing on maximizing the effects and opportunities of networked culture. Before that, she was the Executive Creative Director at frog design, where she led the design research and design strategy practices worldwide. Casey was also an Associate Partner at Pentagram Design, where she started the interaction design group.

Casey is the founder of the Designers Accord, the global design coalition of designers, educators, and business leaders focused on creating positive social and environmental impact. Casey founded the non-profit in 2007, and through her leadership, it has grown to be one of the most influential organizations in the design world. Fast Company writes that Casey's vision around design thinking and impact is "on a path to change the culture of the creative community from bottom to top, and with it, the way everything is made, from toothbrushes to airplanes."

Casey speaks globally on systems thinking, cultural change, and sustainability, and is an Adjunct Professor in the graduate design program at CCA. She holds a master's degree in cultural theory and design from Yale University and a BA from Swarthmore College.